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Sexual differentiation in humans is the process of development of sex differences in humans. It is defined as the development of phenotypic structures consequent to the action of hormones produced following gonadal determination. The development of sexual differences begins with the XY sex-determination system that is present in humans, and complex mechanisms are responsible for the development of the phenotypic differences between male and female humans from an undifferentiated zygote.

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Chapter 7 Sexual Differentiation. Sexual differentiation is a sequential process that begins at fertilization with the establishment of chromosomal sex, continues with the determination of gonadal sex, and results in the development of secondary sexual characteristics that comprise the male and female phenotypes. He explained the results of castration experiments in fetal rabbits.

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Sex determination refers to the mechanisms employed by organisms to produce offspring that are of two different sexes. First we present an overview of the sex determination mechanisms used by mammals. Then we discuss the great variety of mechanisms used by animals other than mammals.

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NCBI Bookshelf. Primary sex determination is the determination of the gonads. In mammals, primary sex determination is strictly chromosomal and is not usually influenced by the environment.

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